9 Best MIDI Sequencers That I SERIOUSLY Recommend (2025)

MIDI sequencers are one of the most important tools in music production. 

They let you program melodies, trigger drum sounds, control synthesizers, and sequence entire tracks all day. 

Plus, they can help you stay locked in with tight timing, automate complex changes, and bring hardware and software together, which is a game-changer, trust me.

As producers, knowing which MIDI sequencers are the best can seriously level up your workflow/skills.

You’ll be able to build drum patterns, sequence synths, play around with automation, and sync everything together like a boss.

That’s why I’m breaking down the top MIDI sequencers available right now, each packed with features like:

• Step sequencing for precise note programming ✓
• Polyphony for layering multiple notes at once ✓
• MIDI input and output for controlling external gear ✓
• Automation for dynamic movement in your tracks ✓
• Integration with drum machines, synthesizers, and samplers ✓
• Dedicated drum sequencers for tight rhythmic control ✓
• USB connectivity for hooking up to your DAW and controllers ✓
• Piano roll editing for advanced MIDI sequencing ✓
• Real-time recording for hands-on performance sequencing ✓
• Much more ✓

After today’s breakdown, you’ll know which MIDI sequencers are the best for performance, beat-making, and full song production. 

Plus, you’ll be able to sequence tracks from scratch, control external MIDI gear, automate synths and effects, and build dynamic patterns like the pros. 

And yes — unlike other articles, I’m breaking down all the features and functions of each, not just a few sentences.

9 Best MIDI Sequencers

So, now that you know how MIDI sequencers can take your production skills to the next level, let’s get into the fun part: the absolute best MIDI sequencers available right now. Every single one on this list is built for serious producers, helping you sequence full tracks, control MIDI gear, automate parameters, and create next-level grooves.

#1. Elektron Digitakt II

If you’re looking for a powerful hardware MIDI sequencer that blends deep sampling, advanced sequencing, and epic performance, Elektron Digitakt II is a beast.

It’s built to last, with a rugged aluminum chassis, high-quality tactile buttons, and a crisp OLED display that keeps everything clear and easy to navigate.

Whether you’re in the studio or performing live, it’s got you covered. 

The 64-step sequencer is as deep as it gets, with: 

• Individual track lengths
• Per-step automation
• Elektron’s signature conditional trigs

With them, you can create sequences that feel organic, evolving, and unpredictable every single time.

Unlike the first Digitakt, the Digitakt II finally brings stereo sampling, which means you’re no longer stuck in mono when chopping samples. 

You also get 16 stereo tracks that can be used for both audio playback and MIDI sequencing, so it’s perfect for controlling external synths, drum machines, and DAW instruments. 

Storage is another major upgrade, with 20GB of internal memory and 400MB of sample RAM per project, so you can load massive sample libraries without worrying.

Elektron also added a Euclidean sequencer mode 一 making it easy to generate complex drum patterns without manually placing every hit. 

The expanded FX section is another game-changer, featuring individual track delay, reverb, chorus, an updated compressor, and bit-crushing effects.

And remember, all of them can be tweaked and automated per step. 

But my personal favorite feature would have to be the parameter locks…

The ability to automate nearly every setting on a per-step basis (from pitch and filter cutoff to sample selection and FX sends) gives you complete control over how a sequence evolves. 

Whether you’re looking to build intricate grooves, tweak synth patterns, or make dynamic, shifting loops, the Digitakt II is one of the best around.

With deep sequencing power, expanded storage, and intuitive performance controls, this one-stop-shop is perfect for beatmakers of all genres/styles.

Why It’s One of the Best MIDI Sequencers (Key Features):

• 64-step sequencer with per-step automation and conditional trigs
• 16 stereo tracks for both audio playback and MIDI sequencing
• Stereo sampling with 20GB internal storage & 400MB per project
• Euclidean sequencer mode for generating evolving rhythms
• Expanded FX section with delay, reverb, chorus, and bit-crushing
• Built-in compressor for punchy, well-balanced mixes
• Deep parameter locks (personal favorite) for hands-on sound shaping
• One of the best hardware MIDI sequencers in the game

#2. Arturia KeyStep Pro

The Arturia KeyStep Pro is hands down one of the best hardware MIDI sequencers I’ve ever used. 

If you’re tired of clunky, frustrating sequencers that make you dig through menus just to get a simple idea down, it changes everything. 

It’s got four independent sequencer tracks, so you can sequence multiple synths, drum machines, or even your DAW all at the same time without feeling boxed in. 

Each track gives you 64 steps per sequence, and you can lock in 16-note polyphony per step, so stacking chords, basslines, and leads together feels easy as hell. 

Also, the 37-key slim keyboard is actually super playable, with velocity and aftertouch sensitivity that responds to every little nuance of your playing. 

On top of that, each key has an LED above it, so you always know what’s active when you’re programming a sequence or jamming live.

Now, here’s where it really stands out: the 24-part drum sequencer 一 if you’re making electronic music or anything beat-driven, it’s straight up insane. 

You get 24 drum lanes, so you’re able to program huge percussion patterns all day without running out of space (big bonus).

It also lets you mess with polyrhythms, so you can get creative with off-grid, evolving drum patterns that most sequencers can’t handle. 

Plus, the connectivity on this thing is next level because you get: 

• Four CV/Gate/Mod outs
• Eight drum gate outs
• MIDI In
• Two MIDI Outs
• USB
• Even a built-in metronome speaker

Whether you’re running a DAW setup, modular synth rig, or drum machines, it all just works, unlike some other MIDI sequencers out there.

Plus, the built-in arpeggiator is loaded with seven different modes, and the chord mode lets you slam out full chords just by hitting one key.

It’s really a lifesaver when you’re sketching ideas fast.

My fav feature would have to be the real-time recording and step editing. 

Being able to jam out a melody, instantly loop it, and tweak every single step on the fly makes it feel fluid, fast, and fun. 

You don’t get bogged down in menus; you just create. 

Bottom line, if you need a rock-solid sequencer that can handle MIDI, modular gear, and drum programming without slowing you down, the KeyStep Pro is a no-brainer.

Why It’s One of the Best MIDI Sequencers (Key Features):

• Four independent sequencer tracks for full control
• 64 steps per sequence with 16-note polyphony per step
• 24-part drum sequencer for deep beat programming
• Next-level connectivity: CV, Gate, MIDI In/Out, USB
• Seven-mode arpeggiator + chord mode for quick ideas
• Real-time recording & step editing (personal favorite)
• One of the best hardware MIDI sequencers in the game

#3. OXI Instruments One

The OXI Instruments One is a super powerful MIDI sequencer that somehow manages to be small, crazy deep, and insanely fun to use all at the same time. 

It comes with 4 completely separate sequencers, and you can switch them into different modes like: 

• Mono for single-line melodies
• Polyphonic for chords (up to 7 voices)
• Chord mode for super fast progressions (up to 8 voices)
• Multitrack for controlling 8 things at once
• Even a Stochastic mode that introduces controlled randomness

That alone makes it one of the most flexible hardware sequencers/MIDI sequencers out there if you ask me. 

Each sequencer gives you 128 steps per pattern, and you can store 16 patterns per sequencer across 15 projects, so don’t worry about space.

The connectivity is next-level as well, and that’s what really sets it apart. 

You get 8 CV and 8 Gate outputs, perfect for hooking up modular synths or analog gear, MIDI In and Out via TRS jacks, Clock In and Out to sync everything perfectly, and USB-C for both power and MIDI.

Feel free to run it straight into your DAW without needing an extra MIDI interface. 

But the coolest part is that it has Bluetooth 5.0 MIDI, which lets you connect it wirelessly to your iPad, Mac, or even your phone and start sequencing soft synths without cables.

When it comes to the interface, it’s super intuitive, with a bright OLED display, 128 RGB pads, and four push encoders that make sequencing and editing feel natural.

There’s also real-time audio recording for quickly laying down ideas.

And, if you’re like me and like tweaking things on the fly, you can dive into step editing, automation, and probability settings to keep your patterns evolving. 

NOTE: The harmonizer mode is sick… You can lock in custom scales, and every note you play automatically stays in key.

It’s perfect for coming up with fresh melodies when you’re stuck. 

All-in-all, with 8 LFOs, 4 loopers, an arpeggiator, and a built-in battery that lasts up to 8 hours, the OXI One is the kind of sequencer that pushes creativity to the limit.

Why It’s One of the Best MIDI Sequencers (Key Features):

• Four independent sequencers with multiple modes
• 128 steps per pattern with 16 patterns per sequencer
• Intuitive interface
• Huge connectivity: 8 CV/Gate outs, MIDI In/Out, Clock In/Out, USB-C
• Bluetooth 5.0 MIDI for wireless sequencing
• OLED display, 128 RGB pads, and push encoders
• Harmonizer mode (personal favorite) for instant in-key melodies
• One of the best hardware MIDI sequencers in the game

#4. Squarp Instruments Hapax

The Squarp Instruments Hapax is straight-up one of the most advanced hardware MIDI sequencers you can get right now (and it doesn’t get enough hype if you ask me).

It’s built for serious producers, live performers, and sound designers who need deep sequencing control without anything getting in the way.

And the craziest part is it’s the first-ever sequencer to fully support MIDI Polyphonic Expression (MPE)… Sick, right?

That means if you’re using an MPE-capable MIDI controller like the Roli Seaboard or Osmose, it picks up every single glide, slide, and velocity change in real time.

Whether it’s gliding between notes, adding subtle vibrato, or adjusting velocity per finger, it’s always on point.

So, instead of feeling like you’re just programming sequences, it responds like an actual instrument 一 making it an insane tool for expressive music creation.

On top of that, it’s one of the only MIDI sequencers that lets you run two completely separate projects at once.

That means you can flip between different sets of tracks mid-performance, test out two arrangements side by side, or work on completely different ideas without reloading.

Each project gives you 16 tracks, and every track has 8 patterns, which is more than enough room for: 

• Full song mode structures
• Crazy loops
• Evolving sequences

And when it comes to hooking up your gear, it’s solid as well.

It’s got multiple MIDI inputs and outputs, CV and Gate outs for modular gear, and USB, so you can hook it up to synths, drum machines, and your DAW all at the same time. 

And, the 128-pad RGB matrix makes step sequencing super visual, and the dual OLED screens show everything clearly, so say goodbye to second guessing.

You can zoom into specific tracks, tweak automation, and adjust sequences on the fly without breaking your flow. 

Plus, with individual track lengths, probability settings, and per-step automation, your sequences never have to sound rigid, basic, or repetitive.

But, my favorite part has to be the built-in MIDI effects…

You can throw in humanized timing, chance, swing, arpeggiators, and even real-time MIDI LFOs that control velocity, pitch, filters, or external synth parameters.

This means your sequences can evolve in ways that feel organic and professional instead of just looping the same way every time. 

Add to that advanced ratcheting, real-time transposition, and per-step modulation, and you’ve got one of the sickest MIDI sequencers in the industry.

Bottom line, whether you’re working in the studio/your bedroom studio or performing live, the Hapax takes sequencing to a whole new level.

Why It’s One of the Best MIDI Sequencers (Key Features):

• First-ever sequencer with full MIDI Polyphonic Expression (MPE) support
• Dual project system for switching between sets without stopping
• 16 tracks per project with eight patterns per track
• 128-pad RGB matrix and dual OLED screens for easy workflow
• MIDI, CV/Gate, and USB connectivity for full studio integration
• Built-in MIDI effects (personal favorite) for humanizing and manipulating sequences
• One of the best hardware MIDI sequencers in the game

#5. Teenage Engineering OP–XY

Leave it to Teenage Engineering to drop something that looks futuristic but actually delivers next-level MIDI sequencing, live performance tools, and deep sound design.

The OP–XY isn’t just a hardware MIDI sequencer, it’s a groovebox, synth, sampler, and motion-controlled performance tool all packed into a slick, ultra-portable design. 

The 64-step sequencer is flexible 一 letting you build tight loops, full song arrangements, or constantly evolving sequences super easily. 

It also supports 24-voice polyphony so you can layer synths, pads, and drum sounds without worrying about notes cutting off. 

And speaking of sound, it’s loaded with multiple synth engines, ranging from gritty FM textures to warm analog emulations and lush ambient pads.

And when it comes to sampling, the OP–XY makes it ridiculously fun. 

It offers both drum and synth multi-sampling (you can record sounds directly into it, drag in samples via USB, or even resample its own output). 

The stereo signal path keeps everything huge, wide, and polished, whether you’re producing in the studio or performing live. 

Then there’s the built-in effects section that adds even more depth, featuring reverb, delay, chorus, and bit-crushing, all of which can be tweaked in real time.

But here’s where things get next level—the OP–XY features a built-in six-axis accelerometer, turning the entire unit into an expressive motion controller. 

You can tilt, shake, and move it around to control parameters like filter cutoff, pitch, modulation depth, or LFO rate.

It honestly feels less like a sequencer and more like an actual instrument. 

That’s easily my favorite feature because it takes live performance control to a whole new level, letting you interact with your sequences in a way no other sequencer does. 

NOTE: It’s battery-powered with up to 16 hours of use, so it’s one of the best MIDI sequencers for on-the-go production whether you’re in the studio or between gigs.

Why It’s One of the Best MIDI Sequencers (Key Features):

• 64-step sequencer for looping, arranging, and evolving patterns
• 24-voice polyphony for stacking synths, pads, and drums
• Multiple built-in synth engines for diverse sound design
• Drum and synth multi-sampling for grabbing sounds from anywhere
• Stereo signal path for wide, polished sound with built-in effects
• Six-axis accelerometer (personal favorite) for motion-based performance control
• Rechargeable battery with up to 16 hours of use
• One of the best hardware MIDI sequencers in the game

#6. Arturia BeatStep Pro

If you’re looking for a MIDI sequencer that can control both digital and analog gear without slowing you down, Arturia BeatStep Pro is an absolute beast. 

It gives you two independent 64-step sequencers, so you can run melodies, basslines, and synth parts all at the same time.

As well as a 16-track drum sequencer that lets you knock out full drum patterns without even touching your DAW (digital audio workstation).

Unlike a lot of hardware sequencers that feel restrictive, this one keeps your workflow fast, fluid, and hands-on, so I really appreciate that.

It’s also got CV/Gate outputs for running modular synths, MIDI In/Out/Thru for hooking up drum machines and keyboards, and USB for syncing with your DAW. 

That means whether you’re working with vintage hardware, modern synths, or software instruments, it ties everything together flawlessly.

Plus, the step sequencing is smooth too, and you can jump between real-time recording, step programming, and automation without missing a beat.

In my opinion the Randomizer function is dope…

This lets you introduce controlled randomness to your sequences so that patterns evolve and feel more human instead of looping the same way over and over. 

You can dial in how much randomness you want 一 from slight variations to totally unpredictable changes, which keeps your sequences fresh and dynamic. 

It takes a basic sequence and makes it sound alive without needing to program every single step. 

Add in a built-in looper with a touch strip, real-time swing control, and a rock-solid metal chassis, and you’ve got a hardware sequencer that’s built to be the best.

Why It’s One of the Best MIDI Sequencers (Key Features):

• Two independent 64-step sequencers for synths, basslines, and leads
• 16-track drum sequencer for programming full drum patterns
• Massive connectivity: CV/Gate, MIDI In/Out/Thru, and USB
• Randomizer function (personal favorite) for controlled sequence variations
• Built-in looper with a touch strip for hands-on performance control
• Real-time swing and step automation for dynamic sequences
• One of the best hardware MIDI sequencers in the game

#7. Elektron Octatrack MKII

If you’re looking for a hardware MIDI sequencer that does way more than just sequencing, the Elektron Octatrack MKII is another super solid choice.

It isn’t just a MIDI sequencer, it’s an:

• 8-track stereo sampler
• A live performance machine
• A creative powerhouse

Each of the eight tracks can play back samples, process live audio, or even act as a MIDI sequencer for external gear. 

It’s also got real-time pitch shifting and time-stretching, so you can stretch loops, sync samples to your BPM, or completely warp sounds without losing quality. 

The 16-step sequencer is deep, letting you program probability, retrigs, and parameter locks on a per-step basis to make patterns that never get stale.

And when it comes to hands-on control, the Octatrack is insanely fun to mess with. 

The contactless crossfader lets you blend between different effects, filter sweeps, or even entire song sections just by sliding it back and forth.

It’s one of the best performance tools on any sequencer, period. 

You also get high-resolution encoders for super precise tweaking, and the OLED display makes it easy to see exactly what’s happening, even in low light. 

And unlike a lot of other samplers, it has actual stereo inputs and outputs, so you’re not stuck working in mono if you don’t want to be.

There’s also my favorite feature which is the live resampling.

You can grab any sound running through the Octatrack (your synths, drum machines, or even your own voice) and instantly mangle it with effects.

Or, re-sequence it in real time. 

Whether you’re using it in the studio or for live sets, this is one of the best MIDI sequencers if you’re looking for a full-blown performance tool.

Why It’s One of the Best MIDI Sequencers (Key Features):

• 8 stereo tracks for sampling, sequencing, and processing live audio
• Real-time pitch shifting and time-stretching to sync samples 
• Deep 16-step sequencer with probability, retrigs, and per-step automation
• Contactless crossfader (personal favorite) 
• High-resolution encoders for detailed sound sculpting
• OLED screen so you always know what’s happening, even in low light
• Stereo inputs and outputs for true multi-channel audio processing
• One of the best hardware MIDI sequencers in the game

#9. Akai MPC Live III

The new Akai MPC Live III is what happens when a MIDI sequencer, sampler, and full-fledged music production workstation come together in one standalone beast. 

Unlike older MPCs, this one doesn’t need a computer or DAW because it’s got: 

• Its own quad-core processor
• 4GB of RAM
• A full-color 7-inch touchscreen

You can run up to 128 MIDI and audio tracks per project, meaning it can handle entire songs, multiple drum kits, layered synths, and external gear sequencing at once. 

The expanded multi-track recording feature lets you record multiple sources at the same time, whether you’re sampling vinyl, tracking external synths, or layering live instruments. 

And if you’re a finger drummer, the velocity-sensitive RGB pads feel insanely responsive, letting you tap out drum grooves and melodic lines.

And, sample chops with natural dynamics instead of stiff, lifeless beats.

And when it comes to hooking up gear, the MPC Live III is built to be the center of your studio… It has full-size MIDI In/Out, USB-C, CV/Gate outputs, WiFi, and Bluetooth.

So, whether you’re controlling hardware synths, modular setups, drum machines, or even wireless controllers, everything syncs up flawlessly. 

The expanded I/O also means you can route multiple outputs separately, which gives you more mixing flexibility than ever. 

Plus, the SD card slot and internal 16GB SSD make it easy to store massive sample libraries and load them instantly without slowing down performance.

Also, the built-in drum editor gives you complete control over your grooves 一 letting you tweak note velocity, swing, timing offsets, and layering in a way that feels intuitive. 

The automation tools are next-level as well…

You can automate effects, filters, pitch, and modulation in real time, making sequences feel alive and evolving. 

The built-in FX suite includes everything from analog-modeled compressors to lush reverbs, tape saturation, and stereo imaging tools.

You can literally fully mix and finalize your tracks inside the MPC itself.

My favorite feature would have to be the onboard synth engines because, unlike past MPCs that relied mostly on samples and external plugins, this one has fully-fledged virtual synths built-in.

NOTE: The synth engines include wavetable, virtual analog, and FM synthesis, so whether you want thick analog-style basses, shimmering pads, or metallic FM tones, the MPC Live III has you covered. 

I can honestly say, whether you’re building drum loops, sequencing external MIDI gear, or designing synth patches, the MPC Live III is one of the most complete hardware MIDI sequencers ever made, period.

Why It’s One of the Best MIDI Sequencers (Key Features):

• Standalone music production machine with a quad-core processor and 4GB RAM
• 7-inch color touchscreen for hands-on sample chopping, sequencing, and mixing
• 128 MIDI and audio tracks per project for full song creation
• Full-size MIDI In/Out, USB-C, CV/Gate, WiFi, and Bluetooth
• SD card slot and internal 16GB SSD for huge sample libraries
• Built-in drum editor and automation tools for precise sequencing
• Onboard synth engines (personal favorite) 
• One of the best hardware MIDI sequencers in the game

Bonus: Best DAW MIDI Sequencers

If you’re making beats inside a DAW, you need a MIDI sequencer that’s just as powerful as the hardware options. 

And when it comes to software MIDI sequencers, FL Studio is easily the best choice. 

The FL Studio piano roll is hands-down the most powerful step sequencer in any DAW, making it easy to program: 

• MIDI patterns
• Drum sounds
• Complex automation

Unlike other DAWs that make editing feel clunky, FL Studio keeps everything fast and intuitive, so whether you’re tweaking MIDI input, layering tracks, or dialing in automation, it all feels natural. 

And since it supports every major VST and MIDI interface, you can connect hardware controllers, MIDI gear, and external synthesizers without any headaches.

That said, Ableton Live is still one of the most popular DAWs out there, especially for electronic music producers who love looping, real-time triggering, and automation. 

But when it comes to detailed MIDI sequencing, Ableton Live is pretty much the worst.

FL Studio has the better workflow, especially for producers who like drawing in notes, adjusting velocity, and programming MIDI controllers with pinpoint accuracy. 

FL Studio’s piano roll integration with synthesizers, drum machines, and samplers makes it a one-stop shop for MIDI music production.

And yes, you can trigger patterns with step sequencing or real-time recording. 

And since FL Studio handles automation clips better than any other DAW, you get full control over MIDI CC, filter sweeps, pitch bends, and any VST parameter without feeling limited.

One of the biggest game-changers is FL Studio’s chord mode.

It makes it easy to play harmonies, stack layered synths, and trigger full progressions with just a few MIDI notes. 

And if you need to sync external MIDI gear (like a MIDI controller), the MIDI clock integration is rock solid 一 keeping everything locked in tight with drum machines, synthesizers, and controllers. 

Whether you’re editing MIDI in the piano roll, sequencing drums with a step sequencer, or audio recording automation, FL Studio gives you the most precise control.

Final Thoughts

And there you have it: the best, most mind-blowing MIDI sequencers in the game (as of right now, of course). 

Each and every one is designed to elevate your music production, offering unique features and capabilities to suit various creative needs. 

Plus, they can help you seriously streamline your workflow, enhance your live performances, or unlock new realms of musical expression. 

So, it all boils down to your personal preference, specific requirements, and the type of music you aim to create. 

Just remember not to overlook the importance of hands-on experimentation or neglect the integration of these tools into your existing setup. 

Otherwise, you might miss out on their full potential.

As a special bonus, you’ve got to check out these legendary Free Sample Packs that are guaranteed to really enhance your beats.

There’s over 50 free sample packs, MIDI packs, loop packs, and preset packs, all 100% royalty-free, for every genre and style.

Plus, they are all created by the best music producers and sound designers in the industry, so you never have to worry about value or quality.

Trust me, you do NOT want to miss out on these invaluable free samples.

Bottom line, when it comes to all the MIDI sequencers we talked about today, just make sure to choose the one that aligns best with your creative vision. 

And make sure to always stay updated with firmware upgrades, explore all the features these devices offer, and play around with them all day.

This way, your tracks will always be fresh, innovative, and uniquely yours 一 just stay motivated, keep practicing, and never be afraid to think outside the box.

Until next time…